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ZOIs of C + G versus V + G by CS and β-TCP/CS. Representative images of the ZOI assay showing the antimicrobial activity of MRX-4 + gentamicin (C + G) and <t>vancomycin</t> + gentamicin (V + G) released from CS and β-TCP/CS beads over time (A) . Statistical diagram comparing ZOI sizes between C + G and V + G over time (B,C) .
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ZOIs of C + G versus V + G by CS and β-TCP/CS. Representative images of the ZOI assay showing the antimicrobial activity of MRX-4 + gentamicin (C + G) and <t>vancomycin</t> + gentamicin (V + G) released from CS and β-TCP/CS beads over time (A) . Statistical diagram comparing ZOI sizes between C + G and V + G over time (B,C) .
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ZOIs of C + G versus V + G by CS and β-TCP/CS. Representative images of the ZOI assay showing the antimicrobial activity of MRX-4 + gentamicin (C + G) and <t>vancomycin</t> + gentamicin (V + G) released from CS and β-TCP/CS beads over time (A) . Statistical diagram comparing ZOI sizes between C + G and V + G over time (B,C) .
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ZOIs of C + G versus V + G by CS and β-TCP/CS. Representative images of the ZOI assay showing the antimicrobial activity of MRX-4 + gentamicin (C + G) and vancomycin + gentamicin (V + G) released from CS and β-TCP/CS beads over time (A) . Statistical diagram comparing ZOI sizes between C + G and V + G over time (B,C) .

Journal: Frontiers in Pharmacology

Article Title: β-tricalcium phosphate/calcium sulfate loaded with contezolid acefosamil (MRX-4) for antimicrobial potency, prevention and killing efficacy of MRSA biofilm

doi: 10.3389/fphar.2025.1657099

Figure Lengend Snippet: ZOIs of C + G versus V + G by CS and β-TCP/CS. Representative images of the ZOI assay showing the antimicrobial activity of MRX-4 + gentamicin (C + G) and vancomycin + gentamicin (V + G) released from CS and β-TCP/CS beads over time (A) . Statistical diagram comparing ZOI sizes between C + G and V + G over time (B,C) .

Article Snippet: The mixing ratios for the C + G and V + G groups were 800 mg of MRX-4 powder (Shanghai MicuRx Pharmaceutical Co. Ltd., Shanghai, China) with 240 mg of gentamicin powder (Tianxin Ltd., Guangdong, China), and 1000 mg vancomycin powder (Eli Lily and Co., Indiana, United States) with 240 mg of gentamicin powder, respectively, combined with 10 cc of either Genex or Stimulan powder.

Techniques: Activity Assay

CS or β-TCP/CS Mixed with Antibiotics for the Prevention/Killing of Biofilm-Forming Bacteria Count Experiment. CFU counts of MRSA biofilms in the prevention assay after 1 and 3 days of exposure to MRX-4 + gentamicin (C + G) or vancomycin + gentamicin (V + G) loaded on CS or β-TCP/CS beads (A) . CFU counts of MRSA biofilms in the killing assay after 1 and 3 days of exposure to MRX-4 + gentamicin (C + G) or vancomycin + gentamicin (V + G) loaded on CS or β-TCP/CS beads (B) . *p < 0.05, **p < 0.01, ***p < 0.001, ns, No statistical difference. Data are presented as mean ± SD. One-way ANOVA with Tukey’s test was used.

Journal: Frontiers in Pharmacology

Article Title: β-tricalcium phosphate/calcium sulfate loaded with contezolid acefosamil (MRX-4) for antimicrobial potency, prevention and killing efficacy of MRSA biofilm

doi: 10.3389/fphar.2025.1657099

Figure Lengend Snippet: CS or β-TCP/CS Mixed with Antibiotics for the Prevention/Killing of Biofilm-Forming Bacteria Count Experiment. CFU counts of MRSA biofilms in the prevention assay after 1 and 3 days of exposure to MRX-4 + gentamicin (C + G) or vancomycin + gentamicin (V + G) loaded on CS or β-TCP/CS beads (A) . CFU counts of MRSA biofilms in the killing assay after 1 and 3 days of exposure to MRX-4 + gentamicin (C + G) or vancomycin + gentamicin (V + G) loaded on CS or β-TCP/CS beads (B) . *p < 0.05, **p < 0.01, ***p < 0.001, ns, No statistical difference. Data are presented as mean ± SD. One-way ANOVA with Tukey’s test was used.

Article Snippet: The mixing ratios for the C + G and V + G groups were 800 mg of MRX-4 powder (Shanghai MicuRx Pharmaceutical Co. Ltd., Shanghai, China) with 240 mg of gentamicin powder (Tianxin Ltd., Guangdong, China), and 1000 mg vancomycin powder (Eli Lily and Co., Indiana, United States) with 240 mg of gentamicin powder, respectively, combined with 10 cc of either Genex or Stimulan powder.

Techniques: Bacteria